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缺氧诱导因子-1生物学特性的研究新进展 被引量:5

Update on the biological behaviour of hypoxia inducible factor-1
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作者 李国青 张育
机构地区 扬州大学医学院
出处 《实用医药杂志》 2005年第8期749-750,共2页 Practical Journal of Medicine & Pharmacy
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  • 1Gassmann M,Chilov D, Wenger RH. Regulation of the hypoxiainducible factor-1 alpha. ARNT is not necessary for hypoxic induction of HIF-1 alpha in the nucleus. Adv Exp Med Biol,2000,475:87.
  • 2Jiang BH,Zheng JZ,Leung SW, et al. Transactivation and inhibitory do mains of hypoxia inducible factor 1 alpha. Modulation of transcriptional activity by oxygen tension.J Biol Chem, 1997,272;31:19253.
  • 3Christiane Brahimi-Horn, Nathalie Mazure, Jacques Pouysse'gur.Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications. Cellular Signalling 2005,17:1.
  • 4Jaakkola P. Targeting of HIF-alpha to the yon Hippel- Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science, 2001, 292:468.
  • 5Ivan M.HIF alpha targeted for VHL-mediated destruction by proline hydroxylation:Implications for O2 sensing. Science,2001,292:464.
  • 6Epstein AC, Gleadle JM, McNeill LA, et al. C elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell, 2001, 107:43.
  • 7Metzen E,Berchner-Pfannschmidt U,Stengel P,et al. Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing. J Cell Sci, 2003, 116:1319.
  • 8Nathalie M Mazure,M Christiane Brahimi-Horn, Me'lanie A Berta,et al. HIF-1: master and commander of the hypoxic world: A pharmacological approach to its regulation by siRNAs:Biochemical Pharmacology, 2004,68:971.
  • 9Lando D, Peet DJ, Gorman JJ,et al. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev, 2002, 16:1466.
  • 10Carrozza MJ, Utley RT, Workman JL, et al. The diverse functions of histone acetyltransferase complexes. Trends Genet, 2003, 19:321.

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