N-(2-氯苯甲酰基)-N′-[5-(3-吡啶基)-1,3,4-噻二唑-2-基]-硫脲的相转移催化法合成

Phase-transfer-catalyzed Synthesis of N-(2-chlorobenzoyl)-N′-[5-(3-pyridyl)-1,3,4-thiadiazol-2-yl]-thiourea

在PEG-600为催化剂的固液相转移催化条件下用2-氯苯甲酰氯与硫氰酸铵及胺反应,一锅法制得N-(2-氯苯甲酰基)-N-′[5-(3-吡啶基)-1,3,4-噻二唑-2-基]-硫脲Ⅲ.其结构经元素分析、1HNMR、IR和MS证实.

One - pot reaction of 2 - chlorobenzoyl chloride with ammonium thiocyanate and then amine in the presence of polyethylene glycol -600 （PEG -600） as the PTC catalyst yielded N - （2 -chlorobenzoyl） -N′ - [ 5 - （3-pyridyl） -1,3,4 -thiadiazol-2 -yl] -thiourea Ⅲ in good yield. Its structure was confirmed by elementary analysis, MS, IR and ^1H NMR spectroscopy.