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痘苗病毒载体在冠状病毒反向遗传学中的应用 被引量：1

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摘要 反向遗传学方法是研究RNA病毒的主要方法,痘苗病毒载体则是感染性克隆技术的主要媒介,目前这一技术已趋向成熟并扩大其应用领域及对象。本文对痘苗病毒载体的构建、在冠状病毒反向遗传学中的应用情况以及目前该领域的进展作一综述。
作者 韩剑峰 秦鄂德
机构地区 病原微生物生物安全国家重点实验室军事医学科学院微生物流行病研究所
出处 《国外医学（病毒学分册）》 2005年第4期121-125,共5页 Foreign Medical Sciences(Section of Virology)
关键词 痘苗病毒载体 冠状病毒 反向遗传学 感染性克隆技术
分类号 R373 [医药卫生—病原生物学]
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参考文献21

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同被引文献13

  • 1赵恩茂,宋卫兰.动脉炎病毒属病毒的传染性cDNA克隆及其作为疫苗载体的研究进展[J].中国畜牧兽医,2006,33(10). 被引量：2
  • 2Neumann G, Whitt M A ,Kawaoka Y. A decade after the generation of a negative-sense RNA virus from cloned cDNA what have we learned. J Gen Virol,2002,83:2635-2662.
  • 3Rota P A, Oberste M S,Monroe S S, et al. Characterization of a noveleoronavirus associated with severe acute respiratorysyndrome. Science, 2003,300: 1394-1399.
  • 4Snijder E J, Bredenbeek P J, Dobbe J C, et al. Unique and conserved features of genome and proteome of SARS-eoronavirus, an early splitoff from the coronavirus group lineage. J Mol Biol, 2003,331:999-1004.
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  • 8Yount B,Curtis K M, et al. Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci,2003,100:12995-13001.
  • 9Casais R, Thiel V. Reverse genetics system for the avian coronavirus infectious bronchitis virus. Virol, 2001 , 75(24) : 12359-12369.
  • 10Coley S E, Lavi E, et al. Recombinant mouse hepatitis virus strain A59 from cloned, full-length cDNA replicates to high titersin vitro and is fully pathogenic in vivo. J ViroI, 2005,79(5) : 3097-3106.

引证文献1

国外医学（病毒学分册）
2005年 第4期

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