甲壳寡糖抗小鼠运动性疲劳的实验研究

The Effect of Chitooligosaccharide on the Delay of Fatigue in Trained Mice

研究甲壳寡糖对运动小鼠的抗疲劳效用.方法:4周龄昆明种小鼠随机分为对照组、运动组、甲壳寡糖组.运动组和甲壳寡糖组进行4周的游泳训练,最后一次进行力竭游泳后采用心脏取血,肝素抗凝,测定血糖(Gluc)浓度、血乳酸(La)含量和血浆乳酸脱氢酶(LDH)活性.取肝组织和后肢肌肉测定肝糖原(LG)、肌糖原(MG)含量.结果:实验4周后,甲壳寡糖组游泳力竭时间显著延长(P<0.05),Gluc浓度、LG和MG含量高于运动组(P<0.01);而血La含量、血浆LDH活性明显低于运动组(P<0.01).甲壳寡糖组La、LDH、Gluc、LG和MG含量与对照组比较均无显著性差异(P>0.05).结果表明,甲壳寡糖可改善小鼠有氧供能和增进糖原贮备,提高抗疲劳能力.

The effect of Chitooligosaccharide on the delay of fatigue has been studied in the trained mice. Methods： The mice were divided randomly into 3 groups： control group, training group,and Chitooligosaccharide group. The training group and Chitooligosaccharide group had trained 4 weeks, and after the last time they were swum exhaustive, the Glue, La content and LDH activity in plasma, LG content in liver and MG content in muscle were tested. Results： It was found that the Chitooligosaecharide group showed delay of fatigue, Glue, LG and MG contents were significantly higher （ P 〈 0.01 ）, and La content and LDH activity decreased （ P 〈 0.01 ）. There was no statistical significance in La, LDH, Glue, LG and MG among Chitooligosaccharide group and control group（ P 〉 0.05）. These indicated that Chitooligosaccharide can delay exercise - induced fatigue and improve exercise performance.