膀胱癌组织中PTEN的表达及其与微血管密度的相关性

PTEN expression in bladder cancer and the relationship between PTEN and microvessel density

目的研究膀胱癌组织中抑癌基因PTEN的表达及其与微血管密度(MVD)之间的关系,评价PTEN在膀胱癌发生发展中的作用。方法应用免疫组织化学SP法检测62例膀胱癌组织和18例良性膀胱病变组织中PTEN的表达和MVD,同时结合肿瘤分期分级进行分析。结果62例膀胱癌组织中PTEN阳性率为53.23%(33/62),18例良性膀胱病变组织PTEN全部阳性表达;PTEN的表达与肿瘤分级密切相关(P<0.05);肿瘤组织MVD明显高于良性病变组织;PTEN表达与MVD呈负相关(P<0.05)。结论PTEN基因突变或缺失所导致的表达障碍可能在膀胱癌的恶性进展和血管生成过程中发挥重要的作用。

Objective To study the expression of anti-oncogene PTEN in bladder cancer and the relationship between PTEN expression and microvessel density（MVD） in tumor tissues. Methods Using immunohistochemical SP Methods, the expression of PTEN and MVD were examined in 62 specimens of bladder cancer tissues and 18 specimens of bladder benign lesions. Results In the 62 bladder cancers, 53.23 % （33/62） was positive for PTEN expression. All bladder benign lesions were positive for PTEN expression. The expression of PTEN was well correlated with tumor grades（ P〈 0.05）. The MVD in bladder cancer was higher than that in benign lesions. There was a negative correlation between PTEN expression and MVD in bladder cancer（ P〈0.01）. Conclusion PETN mutations or deletions might play an important role in tumor progression and angiogenesis of bladder cancer.