5Packer M, Bristow MR, Cohn IN, et al. Effect of carvedilol on morbidity and mortality in chronic heart failure[J]. N Engl J Med, 1996,334(21):1 349～1 355
6MERIT-HF Study group. Effect of metoprolol CP/XL in chronic heart failure metoprolol CR/XL randomised intervention trial in congestive heart failure (MERIT-HF) [ J ]. Lanc, 1999, 353 ( 9 169 ): 2 001 ～ 2007
7Hjalmarson A,Goldstein S,Fagerberg B,et al. Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trail in Congestive Heart Failure (MERIT-HF) [J ]. JAMA,2000,283 (10): 1 295 ～ 1 302
8Packer M. Beta-adrenergic blockade in chronic heart failure: principle,progress, and practice[J ]. prog Cardiovasc Dis, 1998,41 ( 1 ): 39～ 52
9Dandona P, Karne R, Ghanim H, et al. Carvedilol inhibits reactive oxygen species generation by leukocytes and oxidative damage to amino amino acids[J]. Circulation, 2000,101 (2): 122～ 124
10Fisher LD, Moye LA. Carvedilol and the food and drug administration approval process: an introduction[J]. Control Clin Trials, 1999, 20(1):1～15
