西洛他唑对糖尿病微血管病变患者血小板指标的影响

Effects of cilostazol on platelet parameters in the microvascular complicationsof diabetic patients

目的:为了评价西洛他唑对糖尿病微血管病变的防治作用。方法:对120例糖尿病患者测定平均血小板体积(M PV)、血小板压积(PCT)、血小板分布宽度(PDW)、血小板计数(PLT)四项指标,并对60例伴有微血管病变者进行西洛他唑治疗1个月,观察其治疗前后的变化。结果:1.糖尿病患者M PV、PCT、PDW明显高于正常对照组;有微血管病变患者M PV、PCT、PDW增高更明显。2.西洛他唑治疗后微血管病变患者M PV、PDW明显下降。结论:西洛他唑改善血小板参数,预防微血管病变的进展,对防治糖尿病微血管病变起重要作用。

Object ： To evaluate the effects of cilostazol on the prevention and therapy of diabetic patients with microvascular complications. Methods： Mean platelet volume （MPV）, platelet crit （PCT）, platelet distribution width （PDW） and platelet count （PLT） were determined in 120 diabetic patients and 87 healthy adults. A total of 60 diabetic patients with microvascular complications were orally given cilostazol for 1 month. The changes in MPV, PCT, PDW and PLT before and after administration were observed. Results： MPV, PCT and PDW in diabetic patients were significantly higher than that of controls （ P〈0. 01）， MPV, PCT and PDW in diabetic patients with microvascular complications were significantly higher than that of diabetic patients without microvascular complications （ P〈0. 01）. With daily administration of 100mg cilostazol, MPV and PDW decreased significantly after 1 month （P〈0. 01）. Conclusion： Cilostazol could improve platelet parameters and prevent progression of microvascular diseases. It was particularly effective in diabetic patients with microvascular complications。