摘要
肥胖性2型糖尿病组和非肥胖对照组中肿瘤坏死因子α(TNFα)基因启动子上游-857位点,CT、TT基因型频率分别为0.396、0.020和0.179、0.000,T等位基因频率分别为0.220和0.090,差异均有统计学意义(均P<0.05)。提示该位点突变与肥胖者2型糖尿病的易患性有关。
CT and Tr genotype frequencies of TNF-α gene at-857 site in obese patients with type 2 diabetes mellitus （DM） and control groups without obesity were 0. 396, 0. 020 and 0. 179, 0.000, and T allele 0. 220 and 0. 090, respectively. This finding suggests that mutation is associated with type 2 DM in obese subjects.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2005年第4期323-325,共3页
Chinese Journal of Endocrinology and Metabolism
基金
湖北省自然科学基金资助(2003ABA183)
