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血小板衍化生长因子B在糖尿病大鼠肾皮质中的表达 被引量:5

Expression of PDGF-B in renal cortex of diabetic rat
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摘要 本研究以半定量RT-PCR法测定了糖尿病及对照Wistar大鼠肾皮质血小板衍化生长因子B(PDGFB)mRNA水平,发现糖尿病大鼠为对照组2.5倍,提示PDGFB在糖尿病肾病中起一定作用。 Expression of platelet-derived growth factor (PDGF)-B mRNA was measured by semiquantitative RT-PCR in renal cortex of diabetic and control Wistar rats. The expression of PDGF-B mRNA in renal cortex of diabetic rats was 2.5-fold of normal rats, suggesting that PDGF-B seems to play a role in diabetic nephropathy.
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2005年第4期374-375,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 血小板衍化生长因子B 糖尿病 大鼠 肾皮质 基因表达 细胞生长因子 Diabetic nephropathies Rats, Wistar Platelet-derived growth factor
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  • 1余毅,吴永贵,林善锬,杨海春,吴文辉,陆福明,顾勇.苯那普利对糖尿病大鼠肾皮质血小板衍化生长因子-B及其β受体表达的影响[J].中华肾脏病杂志,1999,15(4):207-210. 被引量:11
  • 2Johnson RJ, Floege J, Courser WG, et al. Role of PDGF in glomerular disease. J Am Soc Nephrol, 1993,4:119-128.
  • 3Young BA, Johnson RJ, Alpers CE, et al. Cellular events in the evolution of experimental diabetic nephropathy. Kidney Int, 1995,47:935-944.
  • 4Nokagawa H, Sasahara H, Haneda M, et al. Immunohistochemical characterization of glomerular PDGF-B chain and PDGF beta receptor expression in diabetic rats. Diabetes Res Clin Pract, 2000,48:87-98.
  • 5Spencer WE, Christensen MJ. Multiplex relative RT-PCR method for verification of differantial gene expression. Biotechniques, 1999,27:1044-1052.
  • 6Wolf G, Ziyadeh FN. The role of angiotension Ⅱ in diabetic nephropathy: emphasis on nonhemodynamic mechanisms. Am J Kidney Dis, 1997,29:153-163.
  • 7Bornfeldt KE, Raines EW, Graves LM, et al. Platelet-derived growth factor distinct signal transduction path ways associated with migration versus proliferation. Ann N Y Acad Sci, 1995,766:416-430.

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