摘要
目的:探讨表皮生长因子受体EGFR和nm23基因在子宫内膜癌中的表达。方法:用免疫组化法检测28例子宫内膜癌中EGFR和nm23基因的表达。结果:Ⅱ、Ⅲ期子宫内膜癌EGFR过度表达率明显高于Ⅰ期(P<0·05),乳头状浆液性腺癌EGFR过度表达率明显高于子宫内膜样癌(P<0·01);nm23基因在G1表达率明显高于G2和G3,无肌层侵犯nm23基因过度表达率明显高于肌层侵犯的病例。EGFR过度表达的5年生存率低于低表达组(P<0·05)。结论:EGFR过度表达可增加肿瘤转移的危险性,可望作预后的独立指标;nm23基因为抑癌转移基因,其过度表达可以增加机体的防御能力,减少转移。
Objective: To investigate the expression of epidermal growth factor receptor (EGFR) and ran23 gene in endometrial adenocarcinoma. Methods: The expressions of EGFR and nm23 gene were examined by immunohistochemistry in 28 cases of endometrial carcinoma. Results: EGFR overexpression was significantly stronger in stage Ⅱ and Ⅲ than that in stage Ⅰ (P 〈 0. 05) , while that in papillary serous carcinoma was significantly higher than that in endometrioid carcinoma (P 〈 0. 01 ) . nm23 gene overexpresssion was significantly stronger in well - differentiated adenocarcinoma ( G1 ) than in those moderately and poorly differentiated ( G2’ and G3) and also in cases without myometrial invasion than in myometrial invasion. The five - year survival rate of EGFR overexpression was significantly lower than that in those with low expression ( P 〈 0. 05 ) . Conclusion: EGFH. overexpression could increase the risk of metastasis in endometrial carcinoma, which could serve as independent index for prognosis; nm23 gene as a carcinoma metastasis inhibitor, its overexpression could enhance the ability of resistance of body to decrease the metastasis.
出处
《中国妇幼保健》
CAS
北大核心
2005年第16期2046-2048,共3页
Maternal and Child Health Care of China