摘要
目的:探讨表皮生长因子受体EGFR和nm23基因在子宫内膜癌中的表达。方法:用免疫组化法检测28例子宫内膜癌中EGFR和nm23基因的表达。结果:Ⅱ、Ⅲ期子宫内膜癌EGFR过度表达率明显高于Ⅰ期(P<0·05),乳头状浆液性腺癌EGFR过度表达率明显高于子宫内膜样癌(P<0·01);nm23基因在G1表达率明显高于G2和G3,无肌层侵犯nm23基因过度表达率明显高于肌层侵犯的病例。EGFR过度表达的5年生存率低于低表达组(P<0·05)。结论:EGFR过度表达可增加肿瘤转移的危险性,可望作预后的独立指标;nm23基因为抑癌转移基因,其过度表达可以增加机体的防御能力,减少转移。
Objective： To investigate the expression of epidermal growth factor receptor （EGFR） and ran23 gene in endometrial adenocarcinoma. Methods： The expressions of EGFR and nm23 gene were examined by immunohistochemistry in 28 cases of endometrial carcinoma. Results： EGFR overexpression was significantly stronger in stage Ⅱ and Ⅲ than that in stage Ⅰ （P 〈 0. 05） , while that in papillary serous carcinoma was significantly higher than that in endometrioid carcinoma （P 〈 0. 01 ） . nm23 gene overexpresssion was significantly stronger in well - differentiated adenocarcinoma （ G1 ） than in those moderately and poorly differentiated （ G2’ and G3） and also in cases without myometrial invasion than in myometrial invasion. The five - year survival rate of EGFR overexpression was significantly lower than that in those with low expression （ P 〈 0. 05 ） . Conclusion： EGFH. overexpression could increase the risk of metastasis in endometrial carcinoma, which could serve as independent index for prognosis; nm23 gene as a carcinoma metastasis inhibitor, its overexpression could enhance the ability of resistance of body to decrease the metastasis.
出处
《中国妇幼保健》
CAS
北大核心
2005年第16期2046-2048,共3页
Maternal and Child Health Care of China
