摘要
Formin蛋白家族由结构相关的蛋白组成,它们都有两个formin同源功能区(forminhomologydomains),FH1和FH2。这些基因上的多种变异均导致动物四肢畸形,提示这些基因在肢体发育中起重要作用。我们自小鼠肢体基因库中分离出了一个新基因:“慢”,该基因含有FH1和FH2。我们检测了该基因在小鼠胚胎及成体的表达情况,并对可能的功能意义进行了讨论。
Formin defines a family of structurally related proteins that have two formin homology domains （FH1 and FH2）. Various mutations in the formin locus result in limb deformity, suggesting that these genes play indispensable roles in the limb development.Here we report the isolation of a novel cDNA, man, from the mouse limb, which contains two conserved FH1 and FH2 domains. Its expression is described and possible functional significance is discussed.
出处
《生理学报》
CAS
CSCD
北大核心
2005年第4期433-438,共6页
Acta Physiologica Sinica
基金
This work was supported by the National Institutes of Health of USA.
