紫球藻对四氧嘧啶糖尿病小鼠血糖的调节

Research on the hypoglycemic effection of marine alga Porphyridium cruentum in experimental diabetic mice

目的研究紫球藻对四氧嘧啶糖尿病小鼠的血糖水平及抗氧化能力的影响。方法用四氧嘧啶建立糖尿病小鼠模型,紫球藻藻粉600mg.kg-1和1200mg.kg-1灌胃给药,连续18d后,测定空腹12h血糖、血浆胆固醇、甘油三酯含量和SOD活性。结果与糖尿病模型组相比,两实验组小鼠的血糖显著降低(P<0.001);血浆甘油三酯水平呈下降趋势。1200mg.kg-1紫球藻给药组小鼠血浆SOD活性显著升高(P<0.01)。结论紫球藻能降低四氧嘧啶糖尿病小鼠血糖并呈现一定的抗氧化能力。

Objective To investigate the hypoglycemic and antioxidation effects ot the red alga Porphyridium cruentum in diabetic mice induced by alloxan. Methods The diabetic models were established by intravenous administration of alloxan 70 mg · kg^-1. Then the diabetic mice randomly were divided into four groups, Among them ,two groups were given ig the algal biomass 600,1200mg · kg^-1,respectively. After 18 days, the contents of blood glucose,plasma lipids and the activities of SOD were detected. Results Compared with the diabetic model, the algal biomass 600,1200mg · kg^-1 could significantly decrease the blood glucose.A trend towards lower plasma triglyceride level was observed in test groups. In addition the activity of plasma SOD was significantly enhanced in high dose group. Conclusion Porphyridium cruentum could reduce the level of blood glucose and effectively enhance the ability of antioxidation in the diabetic mice induced by alloxan.