紫菜多糖的免疫功能增强作用

Immunologic enhancement of Porphyra polysaccharide

目的探讨紫菜多糖对免疫功能低下小鼠的保护作用。方法小鼠腹腔注射不同剂量(0.025,0.050和0.150g.kg-1)的紫菜多糖,每日1次,连续7d,并在给予紫菜多糖的第1d,2d同时注射环磷酰胺造成免疫功能低下模型,第8d检测小鼠的NK细胞细胞毒活性,以及脾细胞分泌IFN-γ和NO的水平。结果0.150g.kg-1紫菜多糖组小鼠的NK细胞毒活性、脾细胞分泌IFN-γ及NO的水平均高于模型组。结论紫菜多糖具有一定的免疫功能增强作用。

Objective To investigate the immunologic enhancement of Porphyra polysaccharide. Methods Porphyra polysaccharide in different dosages （0. 025,0. 050,0. 150g · kg^-1）were injected intraperitoneally into the immunosuppressive mice induced by cyclophosphamide for 7d. On day 8,the cytotoxic activity of NK cells,the levels of interferon-γ（IFN-γ）and nitric oxide （NO）in the cultured supernatants of spleen cells were determided. Results The cytotoxic activity of NK cell, the levels of IFN-γ, and NO produced by cultured spleen cells from the group of mice treated with 0. 150g · kg^-1 of Porphyra polysaccharide were higher than those from model group. Conclusion Porphyra polysaccharide could enhance immunological functions to a certain degree in immunosuppressive mice.