龙胆泻肝颗粒的保肝利胆作用研究

Study of hepatic-protective and choleretic effect of Longdanxiegan Keli

目的研究龙胆泻肝颗粒的保肝利胆作用。方法观察不同剂量的龙胆泻肝颗粒对CCl4引起的小鼠实验性肝损伤和大鼠胆汁分泌作用。结果龙胆泻肝颗粒(2·40、4·80、9·60g/kg,ig)可使实验性肝损伤小鼠血清中升高的ALT、ALP值显著降低,改善CCl4引起的动物肝细胞浆疏松化和气球样变,以及肝细胞的脂肪变性和肝细胞坏死。龙胆泻肝颗粒(2·70、5·40g/kg)十二指肠给药可明显增加大鼠的胆汁分泌量,在给药30min已很显著,60min时作用更强。结论龙胆泻肝颗粒对小鼠实验性肝损伤有明显的保护作用,对大鼠具有显著的利胆作用。

Objective To investigate the effects of Longdanxiegan Keli on hepatic-protective and choleretic. Methods To investigate the effects of different doses Longdanxiegan Keli on experimental liver injury in mice and the eolagogue action in rat. Results Intragastrie administration of Longdanxiegan Keli （2.40,4.80,9.60 g/kg） decreased the increased ALT and ALP levels in serum of liver injury＇s mice, ameliorated the degree of carbon tetrachloride-induced hepatoeyte puffing, balloon transform, steatosis and hepatoeyte necrosis. Duodenum administration of Longdanxiegan Keli （2.70,5.40 g/kg）significantly increased secretory volume of eholeresis begun at 30 min and top at 60 min after drug treatment. Conclusion Longdanxiegan Keli is effective in hepatic-protective in mice and eholeretie in rat.