摘要
目的探讨血清E-选择素在冠心病患者中的变化及其意义.方法冠心病患者70例,其中稳定型心绞痛(SA组)24例、不稳定型心绞痛(UA组)24例和急性心肌梗死(AMI组)22例;同时选择30例冠状动脉造影阴性者作为对照组.Gensini积分法评价冠状动脉病变程度,将70例冠心病患者分为两个亚组:A组22例(Gensini积分1～20),B组48例(Gensini积分＞20).酶联免疫吸附法检测E-选择素水平,并进行比较.结果血清E-选择素水平冠心病各组均显著高于对照组(均为P＜0.01),冠心病各组间亦有显著性差异(均为P＜0.05);B组血清E-选择素显著高于A组(P＜0.05).结论 E-选择素可能参与了冠心病的发病过程,且与冠状动脉粥样硬化程度有关.
Objective To investigate the changes of serum E-selectin in patients with coronary heart disease （ CHD ） and its clinical significance. Methods 70 CHD cases included 24 with stable angina （ SAP group ） ,24 with unstable angina （UA group） ,22 with acute myocardial infarction （AMI group） and 30 with coronary angiography negative （ control group）. The Gensini scoring was used to determine the severity of coronary lesions. CHD group was divided into 2 groups by the Gensini scoring： group A （n=22, Gensini score 1-20） and group B （n=48, C, ensini score 〉20 ）. The serum level of E-selectin was measured by enzyme linked immunoadsorbent assay （ELISA）. Results The serum levels of E-selectin in patients with CHD were higher than those in control group （ P〈0.01 ）. There was a significant difference among groups of CHD patients （ P〈0.05 ）. The serum levels of E-selectin in group B were significantly higher than those in group A （ P〈0.05 ）. Conclusion E-selectin may be involved in the pathogenesis of coronary heart disease,which is related with the severity of coronary atherosclerosis.
出处
《中国综合临床》
北大核心
2005年第10期876-878,共3页
Clinical Medicine of China
