空间参考记忆和空间工作记忆检测阿尔茨海默病模型的研究

Examination of Alzheimer's disease model with spatial reference memory and spatial working memory

目的:损伤大鼠双侧基底核形成阿尔茨海默病(AD)模型,用空间参考记忆和空间工作记忆共同检测该模型的可靠性。方法:选用3月龄大鼠16只,随机选8只制成模型组,将鹅膏蕈酸钠(IBO)注入大鼠双侧基底核,其余8只为青年对照组。另选24月龄大鼠8只为老年对照组。用Morris水迷宫对3组大鼠进行行为学检测。结果:模型组与青年组、老年组相比,空间参考记忆和空间工作记忆均明显下降(P<0.01)。结论:空间参考记忆和空间工作记忆是检测AD模型的可靠方法。

Objective： To explore the reliability of Alzheimer＇s disease （AD） model in rats with spatial reference memory and spatial working memory. Methods： Sixteen young rats （3 months） were divided into model and young control groups. The former was injected ibotenic acid （IBO） into bilateral nuleus basalis. Another 8 senile rats （24 months） were acted as senile control group. Ethological examination was tested with Morris water maze. Results： The spatial reference memory and spatial working memory of the model group declined more significantly than those of the young and senile control groups （P〈0.01）. Conclu- sion： The spatial reference memory and spatial working memory are reliable methods to examine AD model.