二甲双胍治疗多囊卵巢综合征的临床疗效观察

Clinical effect of metformin in treating polycystic ovary syndrome

目的:探讨二甲双胍治疗多囊卵巢综合征(polycysticovarysyndrome,PCOS)的作用及机制。方法:选择30例PCOS患者作为研究对象,口服二甲双胍,1500mg/d,连续12周。观察服用二甲双胍后患者的临床特征、性腺激素及糖代谢指标的变化。结果:PCOS患者经二甲双胍治疗后,BMI、WHR、LH、LH/FSH比值、T、A、DHEAS、FI、HomaIR、Homaβcell均较治疗前明显降低(P<0.01,P<0.05),ISI较治疗前明显增高(P<0.05)。结论:二甲双胍可显著改善PCOS患者的临床特征,其机制与二甲双胍降低胰岛素水平、提高胰岛素的敏感性密切相关。

Objective ： To explore the effect and mechanism of metformin on patients with polycystic ovary syndrome （PCOS）. Methods： Thirty patients with PCOS were selected to take metformin of 1500mg daily for 12 weeks, and they were observed the changes of their clinical features, reproductive hormones and glucose metabolisms. Results： BMI, WHR, LH, LH/FSH ratio, T, A, DHEAS, FI, Homa IR and Homa β cell were decreased significantly （P〈0.01 ,P〈0.05）, but ISI was increased significantly （P〈0.05）,Conclusion： Metformin may effectively improve the clinical features of PCOS, which may be related to its improvement on insulin resistance .