谷氨酰胺对伴有营养不良的COPD患者治疗效果

Analysis of the therapeutic effect of glutamine on COPD patients with malnutrition

目的观察谷氨酰胺对慢性阻塞性肺疾病(COPD)患者的治疗效果。方法将50例COPD患者随机分为Glu组和对照组。将用药前后的蛋白质代谢、营养状况、免疫功能、细胞因子的资料进行分析。结果Glu组用药后蛋白质代谢、营养状况、免疫功能均明显好转,IL6、TNF较前明显下降。结论谷氨酰胺可改善COPD患者的营养及免疫等状况,从而改善预后。

Objective To observe the therapeutic effect of glutamine in COPD patients with malnutrition. Methods 50 patients were randomly divided into 2 groups： Glutamine group and control group. To analyze the data of the protein metabolism, nutritional condition, immune function and cytokine with or without drugs. Results In glutamine group, the protein metabolism, nutritional condition, immune function were improved and IL6, TNF significantly decreased. Conclusion Glutamine is not only effective of nutrition support in COPD, but also improves patients＇ immune function significantly. It could enhance effects of nutrional support and improve prognosis.