婴幼儿肠套叠空气加压灌肠治疗前后氧自由基产生和血浆心钠素改变的动态观察

Changes of blood MDA,SOD and ANP in the intussusception patients treated by aero-pressor-therapy

目的测量婴幼儿肠套叠空气加压灌肠治疗前后血中过氧化脂质浓度和超氧化物歧化酶(SOD)活性及血浆心钠素(ANP)的改变。方法测定33例婴幼儿肠套叠空气加压灌肠治疗前和治疗后24h内,血中过氧化脂质浓度、SOD活性和ANP水平。结果33例婴幼儿肠套叠空气加压灌肠治疗前血浆ANP明显高于正常对照组(P<0.05);空气加压灌肠刚复位后血浆中过氧化脂质含量短时间内迅速上升,过氧化脂质浓度与SOD活性之间具有正相关关系(r=0.901,P<0.05)。治疗后24h过氧化脂质浓度与SOD活性和血浆ANP又恢复正常。结论对于婴幼儿肠套叠,空气加压灌肠刚复位后存在再灌注过氧化损伤过程。

Objective To observe the changes of cardiac endocrinology system and blood concentration of MDA and SOD in the intussusception patients treated by aero-pressor-therapy. Methods 33 intussusception patients underwent the measurements of the plasma natriuritic polypeptide （ANP）, MDA, and SOD before and after treatment. Results In 33 intussusception patients concentration of ANP before the aero-pressor-therapy was significandy higher than the normal control group（ P〈0.05）. After the aero-pressor-therapy the plasma concentration of MDA and SOD increased at once（P〈0.05）, while went to normal soon. The plasma level of ANP decended to normal too. Conclusion After aero-pressor-therapy, the intussusception patients have a high level of plasma MDA and SOD, which indicates that there is a reperfusion injury in intestine.