长托宁和东莨菪碱用作甲状腺手术患者术前用药的比较

Comparison of penehyclidine hydrochloride and scopolamine to thyroid operation as premedication

目的对比研究甲状腺手术患者术前用长托宁和东莨菪碱的临床效果。方法30例甲状腺手术患者随机分成A、B两组,每组15例,分别在颈丛诱导前半小时肌注长托宁1mg和东莨菪碱0.3mg,记录患者用药前、用药后10min,麻醉前即刻、麻醉后20min的BP、HR、SpO2。结果A组用药后SBP、DBP、HR有下降趋势,麻醉后虽有增高,但与用药前比差异无显著性(P>0.05)。B组用药后SBP、DBP、HR有上升趋势,以麻醉后20min最明显(P<0.01),用药后两组间各时点的SBP、DBP、HR比差异有显著性(P<0.05～0.01)。结论长托宁比东莨菪碱更适合用于甲状腺手术患者术前用药。

Objective To compare the effect of ponehyclidine hydrochloride and scopolamine to thyroid operation as premedication. Methods group A was injected l mg ponehyclidine hydrochloride muscularly while group B was injected 0.3mg scopolamine muscularly. Results SBP,DBP and HR were decreased after injection in the group A. Its were not increase significantly after anesthesia（P〉0.05）however, SBP, DBP and HR were increase significantly, especially at 20 min after the cervical plexus block （P〈0.01）. Conclusion penehyclidine hydrochloride is better than scopolamine to thyroid operation as premedication.