震动伤犬血清皮质醇、胃泌素含量研究

Study of the Levels of Serum Cortisol and Gastrin in Dogs with Vibration-Induced Injury

目的:观察震动伤犬血清COR和GAS含量的变化特点,对震动伤犬的伤情分类、临床诊断和临床治疗方案的确定提供依据。方法:在试验时,分别在距爆炸中心地平面0m、100m、200m、300m处设四个点,选择当地家犬34只,采用自由位和右卧位布放在上述四个点。使用放射免疫分析,在爆炸前、后对动物血清中的COR和GAS进行分析。结果:爆后24h犬血清COR和GAS含量即开始下降,爆后第9d和爆后第17d犬血清COR含量仍明显低于爆前值。结论:动物受到震动伤时血清COR水平下降。检测血清COR含量可作为震动伤的辅助诊断手段之一。

Objective To study the changes of levels of serum cortisol and gastrin in dogs with vibration - induced injury for providing better treatment regimen. Methods In this experiment, 8 or 10 domestic dogs were placed on each of four sites away from explosion center about 0, 100, 200, 300 meters respectively. The dogs were standing uncontrolled or lying right side down under anesthesia. Serum cortisol and gastrin levels were detected with RIA beth before and after explosion. Results The levels of serum cortisol and gastrin began to fall about 24 hours after explosin. The serum levels of cortisol were still decreased significantly after 9 days and 17 days. Conclusion The levels of the serum cortisol declined when the animals were injured by vibration. Detection of serum cortisol levels might lead to definitive diagnosis and supplemental treatment with cortical hormones for vibration - induced injury.