长效抗菌材料“洁悠神”对留置导尿管伴随性尿路感染预防的研究

Study on Prevention of Catheter Associated Urinary Tract Infection by Using JUS Long-acting Antibacterial Material

目的:应用具有物理抗菌功能的分子膜性结构材料喷涂在在导尿管表面和尿道口,观察其能否降低留置导尿管伴随性尿路感染(CAUTI)的发生.方法:60例经尿道前列腺电切术(TURP)术后留置导尿管的男性患者,年龄68～79岁.随机分为对照组30例和用药组30例.对照组,按常规行尿道口护理,2次/d;用药组,按常规行尿道口护理后,加用'洁悠神'喷洒于导尿管与尿道口,2次/d.观察两组患者置留导尿管后第3、5、7 d膀胱内尿液标本的细菌培养结果并比较.结果:用药组置管期间尿培养尿路感染病例数显著低于对照组(P＜0.01).结论:对留置导尿管的患者使用长效抗菌材料'洁悠神'进行导尿管表面和尿道口喷洒,可形成一层物理抗菌分子膜,阻止细菌生物膜的形成,有效降低CAUTI的发生.

Objective： To observe the effect of reducing the incidence of CAUTI by spraying the long-acting antibacterial material JUS on the surface of catheter and urethral orifice. Methods： Sixty male patients, aged from 68 to 79, with indwelling catheter after TURP were divided randomly into two groups （control group and treated group） , each consisting of 30 patients. For the control group, their urethral orifice was treated conventionally twice a day ; while for the treated group, in addition to the conventional treatment of their urethral orifice, the catheter and their urethral orifice were sprayed with the long-acting antibacterial material JUS twice a day. Result： The number of cases of urinary tract infection in the treated group during catheterization was evidently less than those of the control group （ P 〈 0.01 ） , so the difference was of remarkable significance. Conclusion： The long-acting antibacterial material, after spraying on the wall of catheter and urethral orifice of the patients with indwelling catheter, may form a layer of physically antibacterial molecular film to prevent the formation of a bacterial biological film and effectively reduce the incidence of CAUTI.