树舌多糖对胃黏膜损伤大鼠胃黏膜PGE_2含量及血流量和黏液分泌的影响

Effects of the polysaccharides isolated from ganoderma applanatum(PGA)on the level of PGE_2 and gastric mucosal blood flow(GMBF) and gastric mucus secretion of rats with gastric mucosa injury

目的:研究树舌多糖对大鼠胃黏膜损伤的保护作用及其机制。方法:采用醋酸法和幽门结扎法复制大鼠胃溃疡模型,分别测定胃黏膜PGE2含量和胃黏膜血流量及胃黏液分泌。结果:与模型对照组比较,多次灌服树舌多糖250～1000mg·kg-1可明显增加大鼠胃黏膜PGE2含量和胃黏膜血流量,对大鼠胃内游离黏液和胃壁黏液的分泌也具有显著的增加作用,且有明显量效关系。结论:树舌多糖通过提高胃黏膜PGE2含量和胃黏膜血流量及胃黏液分泌来加强胃黏膜屏障,这是其保护胃粘膜损伤的作用机制之一。

Objective： To investigate the protective effects of the polysaccharides isolated from ganodenna applanatum（PGA）on gastric mucosal injury in rats and the underlying mechanism. Method： Gastric ulcer was induced by either acetic acid or pylorus ligation in the rats. The level of PGE2 and GMBF, and gastric mucus secretion were examined respectively. Result： After oral administration of PGA （250-1000mg·kg^-1） repeatedly, the level of PGE2 and GMBF were obviously increased in gastric mucosa of rats as compared with the model group. The secretions of both free mucus in stomach and mucus of gastric wall were enhanced apparently by PGA in a dose-dependent manner. Conclusion： PGA could strengthen gastric mucosa barrier by improving the level of PGE2, GMBF and the secretion of gastric mucus, which may be one of the mechanisms underlying the protective effect of PGA on the gastric mucosa during the gastric ulcer.