颈椎病、腰椎间盘突出症与自由基损伤的探讨

Study on the Association of Cervical Spondylosis and Prolapse of Lumbar Intervertebral Disc with Free Radical

应用ＴＢＡ比色法和黄嘌呤氧化酶法测定了颈椎病、腰椎间盘突出症。中医治疗前后血清ＬＰＯ含量和ＳＯＤ活性，及应用大剂量ＶｉｔＣ抗自由基治疗的疗效观察。结果表明：颈椎病、腰椎间盘突出症病人血清ＬＰＯ明显高于对照组（Ｐ＜０．０１），而血清ＳＯＤ活力却比对照组明显降低（Ｐ＜０．０１）。中医治疗后同治疗前相比较，血清ＬＰＯ明显下降（Ｐ＜０．０１），血清ＳＯＤ活力有所提高（Ｐ＜０．０５），但是，血清ＬＰＯ，或从ＬＰＯ／ＳＯＤ比值上看仍没有恢复到正常人水平。而使用ＶｉｔＣ治疗组有效率明显高于非ＶｉｔＣ治疗组。提示：颈椎病、腰椎间盘突出症的发病与自由基损伤有关。清除自由基、提高ＳＯＤ活力可能是中医治疗颈椎病，腰椎间盘突出症的机制之一。

he concentration of LPO and activity of SOD in the serum of patients with cervical spondylosis(CS)and prolapse oflumbar intervertebral disc(PLID)before and after chinese,medicing treatment,were determined by means of TBA and xan-thine oxidase method.At the same time the patients were treated with the high-dose vitamine C,an anti-free radical drug.The results revealed:the level of LPO in the serum of patients with CS and PLID is significantly higher than that of controls(P<0.01).the level of LPO in the patients after treatment is markedly decreased(P<0.01 ),but the activity of SOD is in-creased(P<0.05)compate with that before treatment.Furthermore,the levels of LPO and LPO/SOD were still not re-turned to normal after the chinese medicine treatment.The curative effects in patients with using Vit.C therapy were betterthan that in mon-using vit.C .These findings suggest that CS and PLID were associated with free radical.One of the thera-peutic mechanism of chinese medicine on the CS and PLID may be the reduing free radicals and the increasing the activity ofSLD.)