摘要
对离体大鼠心脏用乏氧Ｋ一Ｈ液涨注１５ｍｉｎ后，再用正常Ｋ一Ｈ液复灌，可引发再灌注心律失常（ＲＡ），观察川芎嗪（ＴＭＰ．２０ｍｇ·Ｌ￣（－１））对ＲＡ的影响。结果发现用ＴＭＰ灌注后，ＲＡ发生率显著下降（Ｐ＜０．０１），持续时间也明显缩短，从而提示ＴＭＰ可有效地预防ＲＡ的发生。
The preventive effets of tetramethylpyrazine(TMP)on reperfusion arrhyth-mias(RA)were investigated in isolated Langendorff rat heart.After 15 min anoxic Krebs-Henseleit buffer perfusion followed by 30 min normal Krebs-Henseleit buffer reperfusion,ar-rhythmias were induced. The results showed that incidence of RA in the TMP group was signifi-cantly lower than that in control group (P<0.01).The duration of RA was shortened in TMP group.It is concluded that TMP could effectively reduce the incidence of reperfusion-induced ar-rhythmias.
出处
《九江医学》
1995年第4期196-198,共3页
Jiujiang Medical Journal
