梭曼对大鼠摄食活动的影响

Effects of soman and antidote on food intake in rats

采用记录大鼠每日摄食量的方法研究梭曼及抗毒药对大鼠摄食活动的影响。实验结果表明：大鼠肌注梭曼０．０３５ｍｇ／ｋｇ（０．６ＬＤ＿（５０））使当日摄食量下降３８．３％，抑制作用持续５ｄ。丘脑一下丘脑ＡＣｈＥ活力下降４９％，中毒后１０ｄ尚不能完全恢复，梭曼抑制摄食与其抑制ＡＣｈＥ活力的作用时间相一致。阿托品１０ｍｇ／ｋｇ肌注，可使大鼠当日摄食量下降２１．６％，次日增加１２％，以后恢复正常。ＨＩ－６１０ｍｇ／ｋｇ肌注对摄食无影响，但可部分对抗梭曼引起的摄食抑制。可能中毒早期的摄食抑制是由梭曼和阿托品共同引起的，后期则以毒剂为主，梭曼抑制摄水与抑制摄食的作用基本一致。

The method of recording daily amount of food intake was adopted to study the effects of soman and antidote on food intake in rats. The results demonstrated that amount of food in- take in the first day was reduced 38. 3 %, when soman 0.035 mg/kg was injected intramuscularly. this reduction continued for five days. The activity of acetylcholinesterase(AChE)in thalamus and hypothalamus decreased 49%,and not return to normal level completely ten days after pois-oning.The soman- induced inhibition of food intake was consistent with inhibition of AChE activ-ity.Following intramuscular atropine 10 mg,the amount of food intake decreased 21.6% in theflrst day,then increased 12% in 2nd day,and the amount of food intake returned to normal levelafter 3 days.Following intramuscular HI- 6 10mg,the amount of food intake did not changed,this might be partially resisted to the inhibition of soman- induced.It is suggested that the effectsof inhibition of food intake in the early period of poisoning might be induced by both soman andatropine,but in the later period the effect of soman is more important.