Ⅱ型肺泡上皮细胞在大鼠放射性肺损伤中的变化

The changes of typeⅡpneumocyte in the rat with radiation pulmonary injury

采用光镜、电镜及半定量方法，连续观察了大鼠经胸部照射３０Ｇｙ后Ⅱ型肺泡上皮细胞的变化。结果显示照射后Ⅱ型肺泡上皮细胞数目增多，３个月达高峰。细胞内板层小体数目增多，体积增大，可见巨大板层体出现。Ⅱ型肺泡上皮细胞线粒体肿胀，膜破裂，嵴断裂。对Ⅱ型肺泡上皮细胞与放射性肺损伤的关系亦进行了讨论。

The right or whole thorax of Wistar rat was irradiated with￣60Coγ-ray(30 Gy)。Animals were sacrificed at 0.5,1,2,3,6,9,12 months after irradiation. The changes of type Ⅱpneumocyte were observed with light microscopy(LM),electron microscopy(EM)andsemi-morphometry.Increased number of type Ⅱ pneumocyte,increased lamellar bodies in typeⅡpneumocyte and giant lamellar bodies were observed under electron microscope,swelling andbreaking of mitochondrial membranes in type Ⅱ pneumocyte was also noted.The role of type Ⅱpneumocyte in radiation pulmonary injury is discussed.