维生素E与青蒿琥酯的抗疟机制

Vitamin E and the antimalaria mechanism of artesunate

在鼠疟模型上观察了维生素Ｅ对青蒿琥酯抗疟作用的影响。小鼠口服维生素Ｅ后，在血清维生素Ｅ水平明显升高的情况下腹腔接种伯氏疟原虫，感染鼠用青蒿琥酯或氯喹治疗。结果发现，小鼠补充维生素Ｅ后，青蒿琥酯的抗疟作用减弱，氯喹的抗疟作用与维生素Ｅ无关。流式细胞仪的测定结果表明，青蒿琥酯可抑制疟原虫ＤＮＡ的合成，而补充维生素Ｅ后这种作用减弱。可见宿主体内维生素Ｅ的水平可影响青蒿琥酯的抗疟作用。

The authors tested the effect of vitamin E on artesunate (Art) antimalaria action in arodent malaria model.Mice were fed vitamin E 2 mg/day for 10 days and then inoculated i.p. with Plasmodium berghei .The imfected mice were treated with Art or chloroquine orally.The re-sults showed that imn vitamin E supplemented group the antimalaria action of Art decreased,whilethat of cholroquine not change.Also,data from flow cytometry showed that the PlasmodiumDNA content was decreased by Art in controls but not in vitamin Esupplemented group. Thus,the antioxidant status of the host may affect the antimalaria effect of Art.