摘要
测定了水貂肠炎病毒无血清细胞培养灭活矿油疫苗和铝胶疫苗免疫接种水貂、豚鼠和家兔的血清HI和SN抗体消长规律,证明豚鼠、家兔或水貂接种疫苗后11~40d的血清HI抗体水平是检定MEV矿油疫苗或铝胶疫苗对水貂的体液免疫力和免疫保护率的经济、简便和可靠的指标,建立了MEV疫苗免疫效力的检定指标及其实验动物模型。
The change laws of the immune serum haemagglutination inhibition(Hl)and serum-neutralizing(SN)an-tibodies levels for minks, guinea pigs and rabbits following inoculation with the inactivated vaccines fromserum-free cell cultures of mink enteritis parvovirus(MEV)with mineral oil or Al(OH )_3 gel adjuvant havebeen determined by the tests by statistical analyses.It has been proved by statistical analyses that the levels ofHI antibody response of guinea pigs, rabbits or minks determined during 11~40 days postvaccination(P.V.)were reliable indexes for monitoring the humoral immune efficiency and immune protective rate of theMEV vaccine with mineral oil or Al(OH )_3 gel adjuvant for minks,thus providing some economic,simple andscientific new indexes and laboratory animal models for monitoring the immune efficiency of MEV vaccines inlarge scale. All these have been extensively used in productive practice in the last several years.
出处
《科技通报》
1995年第2期122-125,共4页
Bulletin of Science and Technology
关键词
水貂肠炎
细小病毒
疫苗
免疫效力
实验动物模型
mink enteritis
parvovirus
vaccines
immune efficiency
laboratory animal models