猕猴原位肝移植术的麻醉

Anesthesia for Orthotopic Liver Transplantation in Rhesus Monkey

选择２０例健康猕猴进行原位肝移植．其中１０例为受体，１０例为供体．麻醉前１０ｍｉｎ肌注阿托品０．０２ｍｇ·ｋｇ－１，均采用全麻插管肌注氯丙嗪，静脉氯胺酮复合麻醉，保持自主呼吸，吸入空气，必要时辅助呼吸，监测ＣＶＰ，ＨＲ，注意受体猴眼睫毛反射．手术时间２９０±３４ｍｉｎ，结果表明：氯胺酮、氯丙嗪双氯合剂应用作猕猴原位肝移植术的麻醉药，具有麻醉作用强，麻醉平稳，维持时间长，对循环、呼吸无抑制，术中能保存猕猴的睫毛反射及吞咽反射，对术后苏醒无影响等优点．

20 healthy rhesus monkeys were selected for undergoing orthotopic liver transplantation.They included 10 recipients and 10 donors.The recipients were received intramuscularatropine 0.02 mg.kg-1 prior to anesthesia 10 minutes,then they were performed allendotracheal intubation and balanced anesthesia with intramuscular chlorpromazine andintravenos ketamine. As rhesus monkey′S breath existed,had they inhaled the air,andwere assisted ventilation if necessity.In course of operation,we monitored CVP,HR andobserved carefully the eyelash′s reflex of the recipients.The time of procecdure was 290 ± 34minutes.The results showed that :ketamine and chlorpromazine which apply to rhesusmonkey as anesthetics of the orthotopic liver transplantation have anesthetic effect deeplyand long time action. They don′t inhibit the circulation and respiration. They can conservethe eyelash′s reflex and the swallowing reflex of rhesus monkey in procedure. They have no ef-fect for consciousness.In addition,the management of some changes in operation is veryimportant.