慢性乙型肝炎与肝癌血清学HBV标志分析

HBV Serum Mark Analysis of Chronic Hepatitis B and Hepatocellular Carcinoma

采用ＥＬＩＳＡ法检测慢性乙型肝炎患者１０８例和肝癌患者７９例血清学５种ＨＢＶ标志，结果为：两组均以ＨＢｓＡｇ，ＨＢｅＡｇ，抗－ＨＢｃ３指标阳性和ＨＢｓＡｇ，抗－ＨＢｅ，抗－ＨＢｃ３指标阳性两种组合常见，分别为６２．０４％和７２．１５％；单项阳性率，ＨＢｓＡｇ，ＨＢｅＡｇ，抗－ＨＢｓ，抗－ＨＢｅ，抗－ＨＢｃ，在慢性肝炎组和肝癌组分别为７５，００％，５４．６３％，３．７０％，３７．９６％，７４．０７％和６７．０９％，１７．７２％，２．５３％，５３．１６％，７７．２２％．上述结果表明，持续ＨＢｓＡｇ，抗－ＨＢｅ，抗－ＨＢｃ单项阳性或同时阳性的患者肝细胞癌变的危险性较大．

Five HBV serum markers were measured with ELISA among 108 patients with chronic hepatitis B and 79 patients with liver cancer．Tow positive combination rates，62．04％and 72．15％ as a result from the two groups，were found in two common combinations，one being made up of three positive markers of HBsAg，HBeAg，and anti－HBc．The other consisting of three positive markers of HBsAg，anti－HBe，and anti－HBc．The separated positive rates of HBsAg，HBeAg，anti－HBs anti－HBe and anti－HBc werw respectively 75．00％，54．63％，3．70％，37．96％ and 74．04％In the chronic hepatitis B group，and 67．09％，17．72％，2．53％，53．16％ and 77．22％In the liver cancer group．The above results showed that the great risk of canceration in hepatic cells lied in the patlents who persistently had either one single positive marker or three positive markers of HBsAg，ant－HBe and anti－HBc．