原发性与转移性肝癌病人LAK活性、IL-2水平及sIL-2R表达

LAK Activity IL-2 and sIL-2R Level in Patients with Primary and Metastasis Liver Carcernoma

作者对26例原发性肝癌(PHC)、28例转移性肝癌(MLC)病人外周血单个核细胞(PBMC)的LAK活性、IL-2水平及sIL-2R表达进行了研究。结果发现,PHC及MLC病人PBMC的LAK活性、IL-2水平下降而sIL-2R表达上升。提示肿瘤病人处于免疫异常状态,检测sIL-2R/IL-2比值,对判断肿瘤病人及转移性肿瘤病人的生物学意义具有重要价值。

LAK activity, IL -2 and soluble IL -2 recepotor (sIL - 2R) of PBMC were studied in 26 patients with primary hepatic carcinoma (PHC) and in 28 patients with metastasis liver carcinoma (MLC). The LAK ac-tivity and IL - 2 of PHC and MLC patients were significantly lower, sIL - 2R/IL - 2 was remarkably increased than those of normai controls;and IL -2 of MLC patients was significantly lower, sIL -2R and sIL - 2R/IL -2 were remarkably enhanced than those of PHC patients. The results showed that the decreased LAK activity, IL -2 and increased sIL - 2R/IL - 2 by PBMC in the patients rnight refiect the immunologic abnormalities and clinical staging,especially in MLC patients.