丙型肝炎核心抗原的肝癌及癌旁表达

Expression of HCcAg on hepatocellular carcinoma and its paracarcinomatous tissue

利用丙型肝炎病毒核心抗原（ＨＣｃｇＡ）单克隆抗体、ＡＢＰＡＰ法对５５例肝癌手术标本（有癌旁）作免疫组化。结果８例阳性（１４．５４％）。其中５例癌细胞有阳性信号。阳性细胞散在分布，浆呈棕色，核阴性。１例癌阳性为包涵体型，其ＨＥ相应部位为毛玻璃状（无毛玻璃者阴性）。５５例中ＨＢｓＡｇ（＋）４３例。８例ＨＣｃＡｇ（＋）中有６例ＨＢｓＡｇ亦阳性。对丙型肝炎致癌机制作了讨论。

Abstract cases of hepatocellular carcinoma (HCC) with paracarcinomatous tissue were studied for hepatitis C core antigen (HCcAg) (monoclone antibodies presented by Prof. FUKAI,Japan ) by ABPAP method of immunohistochemistry, Results showed that 8 cases were positive (14. 54%), Among them there were 5 cases with positive signals in HCC cells. The HCcAg signals were scattered, located in cytoplasm; nuclei negative. In one case, the positive signals of HCC cells were of 'inclusion body type', which were 'ground glass-like' in HE stain, while those HCC cells without ground glass change were HCcAg negative.