精神分裂症患者自杀行为与唾液地塞米松抑制试验

The suicide behaviour of patients with schizophrenia and salivary dexamethasoue suppressioo test.

对３１例精神分裂症患者作了唾液地塞米松抑制试验（ＤＳＴ），以探讨其与自杀行为的关系，其中８例患者同时作了血液ＤＳＴ，以探讨唾液ＤＳＴ与血浆ＤＳＴ的一致性。结果发现，唾液皮质醇与血浆皮质醇浓度显著相关，唾液ＤＳＴ与血浆ＤＳＴ结果一致。脱抑制组与抑制组中有自杀行为者所占比率无显著差异，提示精神分裂症患者的自杀行为与ＤＳＴ相关不显著。在１．５年后的随访中，也未发现ＤＳＴ对精神分裂症患者的自杀行为具有预测作用。

AbstractSalivary dexamethasone suppression test(SDST)was studied in 31 patients with schizophrenia in order to explore the relationship between SDST and suicide attempts.8 cases of them received plasma dexamethasone suppression test simultaneously in order to explore the relationship between plasma DST and salivary DST;We found that salivary cortisol level related to plasma cortisol level closely and the result of salivary DST consists with that of plasma DST, There were no significant differences in rates of patients with suicide attempts between suppression and non-suppression group.