骤停氯氮平与其它抗精神病药对照观察

The effect of abrupt withdrawal of clozapine versus other anti-psychotic drugs.

作者在进行安度利可（ＨＤ）临床研究前，对入组病人停药１周作为原服药物的清除期，结果发现骤停氯氮平比停用其它抗精神病药所致病情波动发生率高、出现早、程度更严重，两者差异极为显著（Ｐ＜０．０ｌ）。氯氮平戒断反应发生率为ｌｌ．ｌｌ％。停用氯氮平所致病情波动或戒断反应均在恢复应用氯氮平后２周内好转。提示临床上使用氯氮平应避免突然停药。

Abstract A statistically significant(P<0.0l)difference in the onset,severity and rate of recurrence was ob-served in patients on clozapine compared to other anti-psychotic drugs。 This more severe reaction fol-lowing clozapine withdrawal had an incidence rate of ll.1%, and ameliorated within two weeks of read-ministration of the drug.The abrupt withdrawal of clozapine in clinical practice should be avoided。