首次发病伴有抑郁症状的精神分裂症临床研究

A clinical study of depresslve symptoms in first-episode schizophrenla.

试图确定首次发病的精神分裂症患者抑郁症状发生率及其严重程度。通过对４６例患者在治疗前及治疗三月后以简明精神病量表（ＢＰＲＳ）、汉密顿抑郁量表（ＨＡＭＤ）、阴性症状评定量表（ＳＡＮＳ）评定。结果发现首次发病精神分裂症的抑郁症状发生率为６３．０％；抑郁症状与精神病性症状关系密切，与阴性症状无明显相关。作者认为抑郁症状是精神分裂症症状的组成部分，随着精神分裂症其它症状的缓解而改善，提示对伴有抑郁症状的首次发病精神分裂症患者不一定需合并抗抑郁剂治疗。

AbstractObjective : To determine the prevalence and severity of depressive symptoms in first-episode schizophrenia. Method : Forty-six patients with first-episode schizophrenia were evaluated with Brief Psychiatric Rating Scale(BPRS), Hamilton thepression Rating Scale(HAMD) and Scale for Assess-ment of Negative Symptoms (SANS)before and three months after treatment. Result : The prevalence of depressive symptoms in first-episode schizophrenia was 63.0%。 Depressive symptoms correlated with positive symptoms, but not with negative symptoms, Depressive symptoms were an integral part of schizophrenia, Discussion : Since Kraepelin distinguished between dementia praecox and manic-depres-sive disorder, many studies demonstrated that symptomatic overlap occurred in these two conditions. In fact, depressive symptoms occurred not only in the later phase of schizophrenia, but throughout course of illness. Their severity was generally milder than major depression, They had a close relationship with psychotic symptoms, but not with negative symptoms. Antidepresants were not necessarily indi-cated.