心脏复跳后输入不同液体对肺超微结构的影响

The Influences of Intravenous Different Liquids on Pulmonary Ultrastructure after Heart Resuscitation

本文用１８只杂交犬随机分为三组，均在戊巴比妥钠３０ｍｇ／ｋｇ肌注麻醉下气管插管，行控制呼吸。右侧进胸，作主动脉阻断缺血停跳２ｍｉｎ后开放。观察了心脏复跳后输入三种不同液体对肺超微结构的影响。Ⅰ组（ＬＲ组）用平衡液２０ｍｌ／ｋｇ以２ｍｌ／ｋｇ／ｍｉｎ输入；Ⅱ组（ＬＲＢＤ组）以１／２平衡液及１／２全血＋地塞米松０．５ｍｇ／ｋｇ按上述量输入；Ⅲ组（ＨＴＳ组）以１０ｍｌ／ｋｇ之７．５％氯化钠输入。结果ＣＶＰ、ＭＡＰ以ＬＲ组上升至基线时间最长，ＨＴＳ组最快，ＬＲＢＤ组介于两者之间。ＬＰＯ三组均有上升，ＬＲＢＤ组迅速下降有显著保护作用。在光镜及电镜下显示ＬＲ组有明显肺间质水肿及Ⅱ型细胞部分损害，ＬＲＢＤ组间质水肿不明显，Ⅱ型细胞亦较完整。故从本实验初步结果，认为以ＬＲＢＤ组之混合液体输入·较好。

he influence of fluid infusions on pulmonary ultrastructure after heart resuscitation was studied in dogs. Eighteen dogs were randomly devided into 3 groups in group LR Ringer,solution,20ml/ks(2ml/kg/min)was insused, in group LRBD,1/2Ringer’s solution + 1/2 whole blood + 0.5mg/kg of dexamasone(same amount andspeed as group LR),and in group HTS,7.5%sodium chloride(10mg/kg),The results show that after heart resus-citation,the time for CVP and MAP to restore the baseline in group LR was the longest and in group HTS theshortest。 The values of LPO in all 3 groups were increased markedly during cardiac arrest.LPO in group LPBDwas decreased rapidly after resuscitation indicating its protective effects。 There were remarkable pulmonary inter-stitial edema and damage to type Ⅱ cells in group LR,slighter tissuse damage in group HTS and very slight damagein group LRBD,It is concluded that the mixed injection of LRBD has an obvious advantage in protecting the pul-monary ultrastructure from cardiac arrest.