静注琥珀胆碱对潘库溴铵作用不同时期的影响

Effect of Succinylcholine on Neuromuscular Blockade with Pancuronium

本文对１０例潘库溴铵作肌松的病人，用外周神经刺激器刺激尺神经和二道生理记录仪行拇指肌力监测，观察了非去极化肌松药在体内消除的三个不同时期静注琥珀胆碱和术毕肌松作用完全消失前注射新斯的明后的肌力变化情况。作者发现：１．潘库溴铵消除过程中应用琥珀胆碱，不论是否发生＊短暂的肌松对抗效应，其后均能较长时间地加强肌松作用。肌松对抗效应的强度随体内残存的非去极化肌松药减少而减弱；２．琥珀胆碱延长潘库溴铵作用后，新斯的明仍然具有快速逆转肌松作用的效果；３潘库溴铵用量大时，后期加注琥珀胆碱不会发生肌肉束颤。文中还对潘库溴铵后注射琥珀胆碱引起的叽松作用性质进行了初步探讨。作者认为潘库溴铵效应将过时，可补注琥珀胆碱加强肌松作用，以满足关腹等短时需要。

he effect of succinvlcholine(Schon neuromuscular blockade of pancuronium was studied in l0 patients recov-ering from.pancuronium.The results:(1)Neuromuscular bIockade of pancuronium was enhanced by beh inJection.(2)Neuromuscular blockade of pancuronium was antagonised quickly by neostigmine after Sch.(3)No fasciculationcould be seen after Sch in case a big dose of pancuronium was administered. It is suggested that sch can be used toenhance muscle relaxation for a short period of time during recovering from pancuronium.