爱肌松在诱导插管中的应用

Endotracheal Intubation with Alloferin

我们对２０例开胸手术病人应用爱肌松行快速诱导插管，发现采用小剂量的前剂量法可明显缩短起效时间。２０例随机分为单次组和前剂量组，每组各１０例。单次组在诱导药物静注后一次静注爱肌松２５０μｇ／ｋｇ。前剂量组则在诱导给药前光静注小剂量爱肌松４０～６０μｇ／ｋｇ，诱导药物静注后再静注爱肌松２００μｇ／ｋｇ，两次爱肌松给药间隔２ｍｉｎ。应用美国Ｎｏｒｃｕｒｏｎ型神经末梢刺激仪刺激尺神经。当全部爱肌松２５０μｇ／ｋｇ静注后开始记录ＴＯＦ达到０的时间。单次组平均２４０ｓ，明显长于分次组１３４ｓ，Ｐ＜０．０１。我们认为，应用前剂量法这一技术在中长手术可以替代Ｓｃｈ，行快速诱导插管。

lloferin was used for endotracheal intubation in patients undergoing thoracotomy. Twenty cases were ran-domly divided into two groups with ten cases each. Alloferin 250 μg/kg was given before intubation in group S.Alloferin 40～60 μg/kg was injected iv. 2 to 3 min before intubation dose of alloferin, 200ILglkg, in group P. Neu-romuscluar blocking effect was recorded in both groups. It was found that the time of TOF from 100%to zero was134s in group P, which was significantly shorter than that(240s) in group S. We conclude that the priming technichas an advantage of quick onset of action for intubation when alloferin is used.