前列腺增生症围手术期血浆PGI_2和TXA_2含量变化的意义

The changes of plasma PGI_2 and TXA_2 in patients with benign prostate hypertrophy in perioperations of prostatectomy

本文对30例前列腺增生手术病人围手术期血浆前列环素(PGI_2)和血栓素A_2(TXA_2)进行测定,发现术后3天、2周(与术前比较)血浆TXA_2明显升高,PGI_2明显下降,两者比值明显升高,患者术后血凝和血管收缩倾向明显加强,而这种倾向可能是围手术期患者心脑血管并发症发生和死亡的主要原因之一。同时还发现并冠心病组(10例)与无冠心病组(20例)这种倾向相似,但并冠心病组PGI_2下降更为明显,从而提示冠心病病人围手术期危险性更大。

Plasma 6-keto-prostaglandin F (6-keto-PGFi.) and thromboxane (TXB),stable metablites of prostacyclin (PGI2) and TXA2 were measured by radioimmunoassay from 30 patients with benign prostate hypertrophy in perioperations of suprapubic transvesical prostatectomy. The results revealed that 6-keto-PGF1a level was lower within two wreeks after operation than that of before one (P<0.05) and as contrast ,TXB level was higher (P<0.05). The ratio of TXB/6-ke-to-PGF1a was increased significantly (P<0.05), It was showed that there was a tendency of in-travascular coagulation and contraction of blood vessel, which was consided to be one of main cau ses of cardiac and brain complications.