摘要
本文分析９４例苯丙酮尿症患者的脑电图，结果异常率为６５％，异常表现以痫样放电为主８０％，少数为背景活动异常（２０％）。年龄越大，脑电图异常程度越重，提示早期治疗可防止或减轻脑损害。有抽搐和智力障碍表现或血苯丙氨酸浓度增高者，脑电图异常程度明显。经治疗后血苯丙氨酸浓度下降，脑电图亦明显改善。提示脑电图可以作为评价本病苯丙氨酸对脑的毒性作用的敏感指标。
Abstract The EEG in 94 patients with phenylketonuria was analyzed.The abnormality rate of EEG was 65%,mainly showing epileptiform discharges(80%),partly showing background activity abnormality(20%).The older the patients,the greater abnormalities,indicating that the brain damage could be prevented or reduced by early treatment.However,patients with convulsions.mental retardation and/or a high blood concentration of phenylalanine exhibited a apparent EEG abnormalities.The concentration of phenylalanine decreased and the EEG abnormalities improved after treatment.These results suggested that the EEG might be served as a sensitive index for evaluating the toxic effects of phenylalanine on the brain.
