皮肤恶性淋巴瘤和淋巴样细胞浸润性疾病核形态测量

Nuclear morphometry in cutaneous malignant lymphomas and lymphoid infiltrates

应用同像分析仪对６９例皮肤恶性淋巴瘤（ＣＭＬ）和４２例皮肤淋巴样细胞浸润性疾病（ＣＬＩ）进行核形态测量，结果示核体积、核面积、核直径和核周径中任何一个指标有助于皮肤生发中心细胞性淋巴瘤（ＣＧＣＣＬ），蕈样肉芽肿（ＭＦ）Ⅲ、ｓｅｚａｒｙ综合征（ＳＳ）和非ＭＦ与ＳＳ之皮肤外周Ｔ细胞淋巴瘤（ＣＰＴＬ）与ＣＬＩ的鉴别，形状因子也可供ＣＧＣＣＬ与ＭＦ、ＳＳ在鉴别上某些参考。根据核体积，初步提出将ＣＬＭ和ＣＬＩ分为大、较大、中、小细胞等４型。

Nuclear morphometry was carried out in 69 patients with cutaneous malignant lymphomas(CML) and 42 patients with cutaneous lymphoid infiltrates(CLIiby means of image analysis apparatus. The results showed that any one parameter of nuclear volumes,muelear areas, nuclear`diameters and nuclear perimeters may be helpful in differentiating CLI from cutaneouss germinal center cell derived lymphomas (CGCCL),mycosis fungoides(MF) Ⅲ ,Sezary's syndndme (SS)and cutaneous peripheral T cell lymphomas other than MF and SS and FF may also provide some references in differentiating CGCCL from MF and SS.We preliminarily suggest that CML and CLI may be divided into 4 cell types: large cells,larger mediumsized cells, smaller medium-sized cells and small cells.