高胰岛素血症与急性脑血管病的相关性研究

Relationship of hyperinsulinemia and stroke:A prospective controlled study.

放射免疫法测定１０５例住院ＣＶＤ病人空腹血清胰岛素值为２５．０９±１９．１１μｕ／ｍｌ，与２２例非ＣＶＤ病人（１４．２７±７．０７μｕ／ｍｌ）和６０例健康供血员（１３．２５±９．７３μｕ／ｍｌ）比较有显著差异，但是脑出血与脑梗塞间无明显差异。推测高胰岛素血症（ＨＩ）病人患ＣＶＤ的相对危险率明显增高，而且ＨＩ可能是脑出血与脑梗塞的共同危险因素。ＨＩ发生ＣＶＤ后预后较差。ＨＩ常伴高血压、ＮＩＤＤＭ、脂代谢紊乱，而且先于这些疾病出现，ＨＩ可视为ＣＶＤ早期预防对象。

AbstractFast serum insulin was measured in 105 consecutive patients hospitalized for acute stroke.The average value in stroke patients(25.09±19.11μu/ml)increased significantly when com-pared with 22 non-stroke patients hospitalized at the same time(14. 27±7.07 μu/ml, P< 0.025),or with healthy blood donors(13. 25±9.73 μu/ml,P<0.01).There was no difference be-tween cerebral infarction and cerebral hemorrhage.Hyperinsulinemia predicts poor stroke out-come. Our data suggest that hyperinsulinemia is a common risk factor for cerebral infaction andcerebral hemorrhage. Usually,hyperinsulinemia is associated with hypertension,NIDDM or fatmetabolic disturbence,and hyperinsulinemia often preexists these disorders. We may regard hyper-insulinemia as an object of early prevent in CVD.