幽门螺杆菌在慢性胃炎患者胃内斑片状分布及与炎症关系的研究

Patchy Colonization of HP in Human Stomach and its Relation with Inflammation

39名慢性胃炎患者在胃窦大弯、小弯、胃体、胃底及十二指肠球部检查了幽门螺杆菌(HP)斑片状分布的情况,结果显示:HP在以上5个部位的阳性串分别为56.4％,61.6％,51.3％,46.2％,5.1％。胃内4个部位在青年组、中年组、老年组的阳性率并无显著性差异(P>0.05)。总计24例HP阳性的病人中多数可在两个或两个以上的部位同时检出HP,只1例病人仅在胃窦小弯部检出HP。结果提示:HP在同一病人可在胃内几个部位同时存在。HP对老年人胃粘膜并无更大的易感性。HP斑片状单独存在的发生率约为4％。

This study aimed to study the patchy colonization of helicobacter pylori (HP) in human stomach. 39 chronic gastritis patients were biopsied at 5 places from each patients at antral greater, corpus, fundus and duodenal bulb to determin the inflammation and HP status by HE and W-S stain. The results showed that HP occurence in above 5 areas are 56.4% , 61.6% , 51.3% ,46.2% , 5.1%, no difference was showed in 4 gastric place(P>0. 05). An age related analysis also suggests that no difference for HP positive rate in 4 gastric locations among young, adult and aged groups (P>0. 05). HP is mostly detected in 2 or more locations in each patients harbouring HP, only 1 patient showed HP colonization in lesser curvature among total of 24 HP positive patients, so the patchy colonization of HP in one location is about 4% , and biopsies at antral and lesser curvature could detected 23 of 24 HP positive patients. Results also suggest that HP could colonized at nearly all stomach, but mostly in antrum, HP is not more preferable to old age patients than young group.