功能性消化不良体表胃电及频谱分析

Cutaneous Electrogastrogram and Spectral Analysis in Functional Dyspepsia

观察了10名功能性消化不良(FD)病人及10名健康人(HS)餐前和餐后4小时的体表胃电频谱变化。结果显示,餐后两组的AP、FZ、FC和FP的峰值均显著增加(P<0.05),两组间差异不显著。FD组FZ(<2.4,>3.8cpm)总发生率10.1％,高于HS组(4.3％,p<0.01),FP也高于HS组(16％和10.8％,P<0.05)。FD组服西沙必利5mg,3/d,7日后FP的异常节律降至11.1％,接近HS组(P>0.05),症状计分和胃排空功能均改善。提示FD组的胃排空延迟和消化不良症状可能与胃电节律紊乱增多有关。西沙必利降低胃电异常节律,FD病人可能存在肌间运动神经元功能紊乱。

The preprandial and 4-hour of postprandial electrogastrogram (EGG) were recorded in 10 health subjects(HS) and 10 functional dyspepsia (FD) with comparable age and sex using spectral analysis. The results showed that peak value of amplitude, FZ, FC and FP increased postpraindually in both HS and FD groups. Total gastric arrhythmia(< 2.4, >3.8 cpm) of FZ was 10.1% and 4.3% in FD and HS group (P<0.01),and ab- normal FP is 16.0 % vs. 10.8 % ( P< 0.05 ) respectively. Cisapride decreased percentage of abnormal FP in FD (from 16% to 11.1% )which was close to HS , it improved symptom score and gastric emptying. We conclude dyspepsia symptoms and delayed gastric emptying might be related tc gastric arrhythmia, cisapride may improve motor neuron function in enteral nervous system.