摘要
本文研究冠心病患者血浆抗凝血酶Ⅲ抗原(AT-ⅢAg)、抗凝血酶Ⅲ活性(AT-ⅢAct)及其比值(AT-ⅢAg/Act)的变化.对象包括急性心肌梗塞23例(AMI组),不稳定心绞痛12例(UA组),稳定性心绞痛15例(SA组),健康体检者20例(对照组).结果AMI组、UA组的AT-ⅡAct较对照组降低(分别为71.5%±26.4%、62.8%±16.5%对88.2%±20.8%,P<O.05、0.01),且低于SA组;而SA组AT-ⅢAct与对照组比较无显著差异.AMI组的AT-ⅢAg高于对照组,并高于UA组.冠心病各组AT-ⅢAg/Act均升高,而以UA组、AMI组为著(P<O.01).认为冠心病患者AT-ⅢAg/Act的变化可能比AT-ⅢAct变化更具重要意义.
The ratio of antithrombin Ⅲ antigen to activity (AT-Ⅲ Ag/Act) in plasma was studied in 23 patients with acute myocardial infarction (AMI),12 with unstable angina (UA) and 15 stable angina (SA) and 20 normal individuals as control. Results showed that AT- Ⅲ activity in AMI or UA was lower than that in the control (71. 5%±26. 4%,62. 8%±16. 5% vs 88. 2%±20. 8% respectively,P<0. 05,0. 01). AT-Ⅲ activity in patients with AMI or UA was also lower than that in SA. AT- Ⅲ antigen in AMI was increased compared to the control or UA. A significant increase of AT-Ⅲ antigen was found in patients with AMI. AT- Ⅲ Ag/Act was increased in group of the SA,UA and AMI in order of degree. The change was significant in UA and AMI(P<0. 01). It was emphasized that AT- Ⅲ Ag/Act might be more useful than AT- Ⅲ activity alone in the evaluation of coronary heart disease.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1995年第3期148-150,共3页
Journal of Clinical Cardiology
基金
国家科委八五攻关项目
