冠心病患者红细胞变形能力与红细胞膜脂质成分和PAF－AH活性关系的研究

The study on correlation of erythrocyte deformability with lipid composition and PAF-AH activity of erythrocyte membrane in patients with coronary heart disease

本文检测了１１２例冠心病（ＣＨＤ）患者红细胞变形能力（ＥＤ）和膜脂质成分及血小板激活因子乙酰水解酶（ＰＡＦ－ＡＨ）活性变化。结果显示，ＣＨＤ病人红细胞滤过指数（ＩＦ）较对照组明显增高（Ｐ＜０．００１）；膜胆固醇（Ｃｈ）、脂质过氧化物（ＭＤＡ）和Ｃｈ／磷脂（Ｃｈ／ＰＬ）明显增高，而膜ＰＬ和ＰＡＦ－ＡＨ活性明显降低，与对照组相比差异有显著性意义（Ｐ＜０．００１）。ＣＨＤ患者ＩＦ与膜Ｃｈ、ＭＤＡ和ＣＵＰＬ呈正相关，与膜ＰＬ和ＰＡＦ－ＡＨ呈负相关。提示ＣＨＤ患者ＥＤ降低与红细胞膜脂质成分异常和ＰＡＦ－ＡＨ活性降低有关。

Abstract The erythrocyte deformability(ED)and lipid composition and platelet activating factor acetylhydrolase(PAF-AH)activity of erythrocyte membrane were measured in 112 patients with coronary heart disease(CHD)and 60 normal controls.The erythrocyte filtration index(IF)was significantly higher in CHD than in controls(P<0.001).The contents of cholesterol(Ch),malonyldiadedvde(MDA)and cholesterol/phospholipid(Ch/PL)ratio of erythrocyte membrane were significantly higher in CHD than in controls(P<0.001),but content of PL and activity of PAF-AH were lower in CHD than in controls(P<0.001).These variations were more obvious in acute myocardial infarction patients.In CHD patients,the erythrocyte IF was positively correlated with the contents of Ch,MDA and Ch/PL ratio of erythrocyte membrane.There was negative correlation of IF with PL content and PAF-AH activity.These results indicated that decreasing of ED in CHD patients was related to abnormalities of lipid composition and decreasing of PAF-AH activity of erythrocyte membrane.