鱼油20碳5烯酸对高脂血症病人血小板功能、血栓形成及血脂的影响

Study of Eicosapentaenoic Acid Effects on Platelet Function,Thrombosis and Plasma Lipids in Patents with Hyperlipoidemia

１０例高脂血症病人口服鱼油２０碳５烯酸（２．７ｇ／ｄ）３０天，于服药前１天及服药后第３０天进行血小板功能、体外血栓形成（包括血栓干、湿长度和重量）及血脂测定。血小板粘附率由服药前的６２．８％±３．５％降到３７．９％±２．１％。肾上腺诱导血小板聚集由服药前的８５．２％±５．７％下降至２３％±８．１％。体外血栓形成的长度和重量由服药前的８．５４ｃｍ±４．９ｃｍ、１４１．２ｍｇ±３８．２ｍｇ降至２．５ｃｍ±１．２ｃｍ，５７．１ｍｇ±１１．７ｍｇ；血浆胆固醇水平服药后也有下降。这些结果提示２０碳５烯酸是治疗和预防高脂血症及冠心病、血栓形成性疾病有希望的药物。

cases of hyperlipoidemia were studied,EPA(eicosapentaenoic) exteracted from fish oil was administered orally(2.7g/day) for 30 days.The platelet retention test measured by Salzman merhod showed that before of administration and after descotinuation of the drug,it was reduced from 62.8%±3.6% to 37.9%±2.1%(P<0.001).while the platelet aggregation induced by Adrenalin from 65.2%±5.7% to 23%±8.1%(P<0.001),the length and weight of thrombosis in vitro were reduced from 6. 54cm±4.9cm,141.2mg±38.2mg to 2.5cm±1.2cm(P<0.001),57.1mg±11.7mg(P<0.001) respectively.The Blood cholesterol and triglyceride level were lowered from 2.13±0.89mmol/L,6.3±0.82mmol/L to 1.33 ±0.46mmol/L (P<0.001),4.72±0.46mmol/l(P<0.005) respectively.There were no significant side effects,The results showed that EPA is a promising drug for inhibiting platelet function,reducing the thrombosis and for the prevention and treatment of the hyperlipoidemia and coronary heart disease.