胃肠道癌组织中AAT、AACT的表达及意义

The expression of AAT, AACT and their biological significances in gastrointestinal cancer tissue

５０例胃癌α１－抗胰蛋白酶（ＡＡＴ）和α１－抗胰糜蛋白酶（ＡＡＣＴ）免疫组化阳性分别为２６例（５２％）和２７例（５４％），６０例肠癌ＡＡＴ和ＡＡＣＴ免疫组化阳性分别为３２例（５３．３％）和３０例（５０％）；ＡＡＴ和ＡＡＣＴ阳性与阴性的胃肠癌比较，前者多分化好、组织学分级多为Ⅰ级或Ⅱ级、癌细胞多侵袭至浅肌层、区域淋巴结转移率低。这些结果提示ＡＡＴ和ＡＡＣＴ阳性胃肠道癌预后较好，ＡＡＴ和ＡＡＣＴ可能是反映胃肠道癌预后的重要生物学标记物。

Twenty-six positive cases of alpha 1-antitrypsin (AAT) and 27 positive cases of alpha 1-antichymotrypsin (AACT) were found by immunohistochemical method in 50 cases of gastric cancer. 32 positive cases of AAT and 30 positive cases of AACT were found by immunohistochemical method in 60 cases of colorectal cancer. Most of the positive gastrointestinal cancers of AAT and/or AACT were well-differentiated, histologic grade Ⅰ or Ⅱ, invasive shallow muscular layer of cancer cells, and lower metastasis rate of regional lymphnodes. The results suggested that the positive gastrointestinal cancer of AAT and/or AACT might have a good prognosis,AAT and AACT might be important biological markers in reflecting the prognosis of gastrointestinal cancer.