摘要
用rasp21单克隆抗体、免疫组化LSAB法,检测128例宫颈癌石蜡包埋标本,119例阳性(92.9%)。其中Ⅰ期17例有10例阳性(58.8%);Ⅱ期53例有51例阳性(96.2%);Ⅲ期58例均呈阳性,rasp21表达强度Ⅲ期明显高于Ⅰ、Ⅱ期(P<0.01),Ⅱ期高于Ⅰ期(P<0.05)。结果显示rasp21的表达与宫颈癌的分期呈正相关,提示rasp21在宫颈癌中高表达时,癌有较强的侵袭性。
Using ras p21 monoconal antibody,the expressions of gene product were detected by labelled strptavidin biotin (LSAB) immunohistochemical methed in 128 cases of uterine cervical carcinoma. Positive expression of ras p21 was observed in 119 cases,stage Ⅰ17 cases, positive 10(58.8%); stage Ⅱ 53 cases, postive 51 (96.2%); stage Ⅲ 58 cases, all postive. The expression of ras p21 was higher in stage Ⅲ than in stage Ⅰ、Ⅱ(P<0.01).It was higher in stage Ⅱ than in stage Ⅰ(P< 0.05). The result suggested that expression of ras p21 might be associated with the biological aggressiveness of cervical carcinomas and that it might be useful in prognosing cervical cancer.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
1995年第4期299-300,共2页
Chinese Journal of Clinical and Experimental Pathology